|
KMID : 0369819950250040313
|
|
Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 4 p.313 ~ p.322
|
|
|
The Effect of Human Recombinant Superoxide Dismutase Conjugated with Polyethylene Glycol on the Hepatic Toxicity of Acetaminophen
|
|
|
|
|
Abstract
|
|
|
The covalent conjugation of human recombinant superoxide dismutase (hrSOD) with trichloros-triazine activated polyethylene glycol(PEG) 5000 formed soluble conjugates with molecular half-life of hrSOD-PEG conjugates on acetaminophen(ACP)-induced
hepatotoxicity was tested in male rats which were pretreated with 3-methylcholanthrene. HrSOD-PEG conjugates inhibited the hepatotoxicity produced by ACP, on the other hand, native hrSOD had no protective effect. The above results indicated that
oxygen
radicals might participate in the mechanism of the ACP-induced hepatotoxicity and that polymer conjugated protein drugs with prolonged half-lives could be employed as an effective therapeutic agent.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|